The seticaudata does best in home aquariums with live rock, ample places to hide, as well as open areas to scavenge.
Seticaudata are very social and peaceful towards most reef inhabitants. Like other invertebrates, the Peppermint Shrimp cannot tolerate copper-based medications or high nitrate levels. It also requires supplemental iodine to encourage proper molting of its carapace. In addition to what it obtains from scavenging, the diet of the Shrimp should consist of most types of prepared foods and the occasional pieces of fresh fish.
The shrimp has been successfully bred by commercial fish farms, and can be bred in the home aquarium. Rearing the larvae requires specialized feeds and care outside of the display aquarium.